Amelogenin, Y isoform is a protein that in humans is encoded by the AMELY gene. AMELY is located on the Y chromosome and encodes a form of amelogenin. Amelogenin is an extracellular matrix protein involved in biomineralization during tooth enamel development.

Clinical significance

Mutations in the related AMELX gene on the X chromosome cause X-linked amelogenesis imperfecta.

The presence or lack of the Y isoform of Amelogenin in fossilized enamel can be used to determine the sex of ancient hominids.

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Further reading