Apigetrin is a chemical compound that can be found in dandelion coffee and in Teucrium gnaphalodes.

Biosynthesis and metabolism

Apigetrin is a glycoside of the flavone, apigenin. Its biosynthesis in plants involves a sequence of enzymes, with chalcone synthase being the one that forms the ring system of the natural product naringenin. Naringenin is then oxidised to apigenin:

Next, the enzyme flavone 7-O-beta-glucosyltransferase transfers the glucose sugar fragment from UDP-glucose, giving apigetrin, with uridine diphosphate (UDP) as byproduct:

Apigetrin is further metabolised to apiin when a second apiose sugar is added by the enzyme flavone apiosyltransferase:

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