Cuore, , the Italian-language word for "heart", may refer to:

• CUORE Experiment, a particle physics facility in the Laboratori Nazionali del Gran Sasso in Italy

• Cuore (magazine), a Spanish women's magazine established in 2006

• Cuore (zine), a satirical insert in the Italian communist newspaper l'Unità 1989–1997

• Daihatsu Cuore, a vehicle built by the Japanese car maker Daihatsu

• Heart (1948 film), an Italian drama film directed by Vittorio De Sica and Duilio Coletti

Heart (novel), an 1886 children's novel by Edmondo De Amicis

• 3000 Leagues in Search of Mother, a Japanese animated television series and film based on the above novel

• Cuore (album), a 1998 album by Gianna Nannini