DFE or DfE may refer to:

Organizations

• Department for the Economy, Northern Ireland

• Department for Education, UK

• DePatie–Freleng Enterprises, a defunct American animation studio

Science

• Difluoroescaline, a psychedelic drug

• Dilated fundus examination of the eye

• Distribution of fitness effects

• Dietary folate equivalent, bioavailability of folate

• 1,1-Difluoroethane

Technology

• Design-focused evaluation of educational quality

• Design for the Environment of a product or service

• DFE Ascender, an ultralight aircraft

Other

• Dragon Fli Empire, a Canadian hip hop group

• Dunfermline Town railway station, Scotland, National Rail station code

• The Duke of Edinburgh's Award, commonly referred to as 'DofE'