ETS2 is a gene that in humans is encoding the C-ETS2 protein. The protein encoded by this gene belongs to the ETS family of transcription factorss. It has been found to play a key role in the development of inflammatory bowel disease.

Interactions

ETS2 has been shown to interact with:

• C-jun,

• Cyclin-dependent kinase 10,

• ERG,

• myb, and

• ZMYND11.

Clinical significance

ETS2 has been linked to a variety of diseases, including Takayasu's arteritis, inflammatory bowel disease, primary sclerosing cholangitis, and ankylosing spondylitis, all associated with a region on chromosome 21 at 21q22.

References

Further reading

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