Guanine nucleotide-binding protein G(i), alpha-2 subunit is a protein that in humans is encoded by the GNAI2 gene. This protein is one of the 4 subunits in the Gi/o family of G-proteins, which together play an important role in inhibitory signaling. Some preliminary evidence suggests that the alpha-2 subunit in particular may be important for adenosine A1 receptor signaling. The A1 receptor is a target of certain drugs that treat tachycardia, and also part of the mechanism of certain stimulants like caffeine (via receptor antagonism). Somatic mutations in the gene have been associated with certain diseases like ventricular tachycardia.

Interactions

GNAI2 has been shown to interact with:

• EYA2

• GPSM2

• Interleukin 8 receptor, alpha

• MDFI

• RGS5

• RIC8A

References

Further reading