G protein-coupled receptor family C group 6 member A (GPRC6A) is a protein that in humans is encoded by the GPRC6A gene. This protein functions as a receptor of L-α-amino acids, cations (e.g., calcium), and osteocalcin. It has also been found to mediate some of the effects of testosterone, but the direct affinity with the receptor is relative low, so the precise mechanism remains controversial.

Clinical significance

GPRC6A has also been linked to prostate cancer progression, and it has been shown to mediate rapid, non-genomic prostate cancer cell responses to testosterone.

See also

• ZIP9

References

Further reading

External links