Gozzadini is an Italian surname. Notable people with the surname include:

• Angelo I Gozzadini (died between 1468 and 1476), Lord of Kythnos

• Angelo Gozzadini (1573–1653), Roman Catholic prelate

• Bettisia Gozzadini (1209–1261), Italian jurist

• Francesco Gozzadini (died 1673), Roman Catholic prelate

• Giovanni Gozzadini (1810–1887), Italian archaeologist

• Iakovos Gozadinos (1716–1786), Greek bishop of Gothia

• Marcantonio Gozzadini (1574–1623), Italian cardinal, cousin of Pope Gregory XV

• Maria Teresa Gozzadini (1812–1881), Italian geologist and countess

• Tommaso Gozzadini (1260–after 1329), Italian notary

• Ulisse Giuseppe Gozzadini (1650–1728), Italian cardinal and bishop of Imola