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Wikipedia / HLA-C

HLA-C (Human Leukocyte Antigen-C) belongs to the MHC class I heavy chain receptors. The C receptor is a heterodimer consisting of a HLA-C mature gene product and β2-microglobulin. The mature C chain is anchored in the membrane. MHC Class I molecules, like HLA-C, are expressed in nearly all cells, and present small peptides to the immune system which surveys for non-self peptides.

HLA-C is a locus on chromosome 6, which encodes for many HLA-C alleles that are Class-I MHC receptors. HLA-C, localized proximal to the HLA-B locus, is located on the distal end of the HLA region. Most HLA-C:B haplotypes are in strong linkage disequilibrium and many are as ancient as the human species itself.

Disease associations

By serotypeserotype

Cw1: multinodular goiters

By alleleallele

C*16: B-cell chronic lymphocytic leukemia

Nomenclature

C*01

  • Cw1 serotype: C*01:02 and C*01:09

  • Cw11

  • C*01:04 to *01:08

C*02

  • Cw2 serotype: C*02:02 and *02:08

  • C*02:03 to *02:07, and 02:09

C*03

  • Cw9 serotype: C*03:03

  • Cw10 serotype: C*03:02, *03:04, and *03:06

  • Cw3 serotype: C*03:07

  • C*03:05 and 03:08

C*04

  • Cw4 serotype: C*0401, *0407, and *0410

C*05

  • Cw5 serotype: C*05:01 and *05:02

  • C*05:03 to *05:06 and *05:08 to *05:10

C*06

  • Cw6 serotype: C*06:02 and *06:05

  • C*06:03, *06:04 and *06:06 to *06:11

C*07

  • Cw7 serotype: C*07:01 to *07:06, *07:12, *07:14, *07:16

  • C*07:07 to *07:11, *07:13, *07:15, and *07:17 to *07:29

C*08

  • Cw8 serotype: C*08:01, *08:02 and *08:03

  • C*08:05 to *08:12

Others

  • C*12:02 to *12:15

  • C*14:02 to *14:05

  • C*15:01 to *15:11

  • C*16:01 to *16:06

  • C*17:01 to *17:03

  • C*18:01 and *18:02

Common haplotype

Cw4-B35 (Western Africa to Native Americans) Cw7-B7 (Western Eurasia, South Africa) Cw7-B8 (Western Eurasia) Cw1-B46 (China, Indochina) Cw5-B44 (Western Eurasia)

Interactions

HLA-C has been shown to interact with:

Leukocyte immunoglobulin-like receptor family:

References

Further reading