Humphrys is a surname. Notable people with the surname include:

• Bob Humphrys (1952–2008), BBC Wales sports broadcaster

• Fletcher Humphrys (born 1976), Australian actor

• Sir Francis Humphrys (1879–1971), British colonial administrator and diplomat

• John Humphrys (born 1943), BBC broadcaster

• Stephen Humphrys, English footballer

• William Humphrys (1794–1865), Irish engraver

See also

• Humfrey, given name and surname

• Humphery, surname

• Humphrey, given name and surname

• Humphreys (surname)

• Humphry, surname

• Humphries, surname