Jefferies is an English surname. Notable people with the surname include:

• Alan Jefferies (born 1957), Australian writer

• Annalee Jefferies (born 1954), American actress

• Axcil Jefferies (born 1994), Zimbabwean racing driver

• Chris Jefferies (born 1980), American basketball player

• Cindy Jefferies, English writer of fiction for children

• Darren Jefferies (born 1993), English footballer

• Daulton Jefferies (born 1995), American baseball player

• Dinah Jefferies (born 1948), English writer

• Gregg Jefferies (born 1967), American baseball infielder

• Jim Jefferies (comedian) (born 1977), Australian comedian

• Jim Jefferies (footballer) (born 1950), Scottish football player and manager

• Jim Jeffries (baseball) (1893–1938), American baseball player

• Matt Jefferies (1921–2003), American artist, set designer and writer

• Richard Jefferies (1848–1887), English nature writer

• Thomas Jeffries, also known as Thomas Jefferies (died 1826), Australian outlaw & prisoner

See also

Jefferies Financial Group, American financial services holding company

• Jefferies Group, financial services subsidiary of Jefferies Financial Group

• Jefferys

• Jeffreys, surname

• Jeffries, surname