Lupi may refer to:

People

• Alessandro Lupi (born 1970), Italian former professional football manager and former player

• Carlos Lupi (born 1957), Brazilian professor and politician

• Daniel Lupi (born 1961), American film producer

• Darrin Zammit Lupi (born 1968), Maltese photographer and journalist

• Didier Lupi Second (c.1520-after 1559), French composer

• Dov Lupi (born 1948), Israeli-American gymnast

• Francisco Lupi (1920–1954), Portuguese chess master

• Giorgia Lupi (born 1981), Italian information designer

• Giovanni Lupi, commonly known as Nino, (1908–1990), Swiss footballer

• Giuseppe Lupi (1894, date of death unknown), Italian gymnast

• Ignazio Lupi (1867–1942), Italian actor and film director

• Italo Lupi (1934–2023), Italian graphic designer and writer

• Johannes Lupi (c. 1506–1539), Franco-Flemish composer

• Leonardo Lupi (born 1972), Venezuelan footballer

• Maurizio Lupi (born 1959), Italian politician

• Miguel Ângelo Lupi (1826–1883), Portuguese painter and art professor

• Roberto Lupi (1908–1971), Italian composer, conductor, and music theorist

• Roldano Lupi (1909–1989), Italian film actor

• Tomás Verón Lupi (born 2000), Argentine professional footballer

• Walter Lupi (born 1960), Italian guitarist

Astronomy

• Any of several stars in the constellation Lupus

Other

• Lupi, Camarines Sur

• Lupeol synthase, an enzyme

• A.S. Roma, a football club known as i Lupi (Italian for "the Wolves")

• A.S. Avellino 1912, a football club known as i Lupi

• Piacenza Calcio, a football club, known as i Lupi

• Lu Pi or Lupi, a village in Kachin State, Myanmar