MLD-41, also known as 1-methyl-LSD, is a psychedelic drug of the lysergamide family related to lysergic acid diethylamide (LSD). It has about 33% of the psychoactive potency of LSD. It has been studied with regard to cross-tolerance with LSD. Extensive metabolism of other 1-methylated lysergamides to their secondary amine derivativess, for instance methysergide (1-methylmethylergometrine) conversion into methylergometrine, has been observed.

Interactions

Pharmacology

Pharmacodynamics

MLD-41 produces the head-twitch response, a behavioral proxy of psychedelic effects, in rodents, and with only slightly lower potency than LSD.

Society and culture

Legal status

Canada

MLD-41 is not a controlled substance in Canada as of 2025.

See also

• Substituted lysergamide

• MLA-74 (1-methyl-LAE)

• MPD-75 (1-methyl-LPD)

• MBL-61 (1-methyl-2-bromo-LSD)

References

External links

• 1-Methyl-LSD (MLD-41) - Isomer Design

• LSD-25 (Discusses MLD-41) - TiHKAL - Erowid

• LSD-25 (Discusses MLD-41) - TiHKAL - Isomer Design