Manfredini is an Italian surname. Notable people with the surname include:

• Achille Manfredini (1869–1920), Italian architect and engineer

• Aparicio Méndez Manfredini (1904–1988), Uruguayan politician

• Christian Manfredini (born 1975), Côte d'Ivoire-Italian footballer

• Elisabetta Manfredini-Guarmani (1780–after 1828), Italian opera singer

• Fernando Salinas Manfredini (born 1956), Chilean activist

• Francesco Manfredini (1684–1762), Italian Baroque composer, violinist, and church musician

• Harry Manfredini (born 1943), American musician

• Niccolò Manfredini (born 1988), Italian footballer

• Pedro Manfredini (1935–2019), Argentine footballer

• Renato Russo (1960–1996), Brazilian musician, birth name Renato Manfredini, Jr.

• Thomas Manfredini (born 1980), Italian footballer

• Vincenzo Manfredini (1737–1799), Italian composer, harpsichordist and music theorist

• Manfredini family of painters (Cremona) from the 18th and 19th centuries, included father Giovanni (1730–90), and his three sons, Paolo (1754–1805), Giuseppe, and Serafino

See also

• Memorial Argo Manfredini, an Italian tennis tournament