Insulin receptor substrates (IRS) are important ligands in the insulin response of human cells.

IRS-1, for example, is an IRS protein that contains a phosphotyrosine binding-domain (PTB-domain). In addition, the insulin receptor contains a NPXY motif. The PTB-domain binds the NPXY sequence. Thus, the insulin receptor binds IRS.

Genes

• (see also Insulin receptor substrate 1)

• (see also Insulin receptor substrate 2)

• - a pseudogene

References