Onofrio is an Italian male given name and surname, derived from the saint Onuphrius. Notable people with the name include:

As a given name

• Onofrio Avellino (1674–1741), Italian painter

• Onofrio Barone (born 1964), Italian football coach and former player

• Onofrio Catacchio (born 1964), Italian comics artist

• Onofrio Fusco (1918–1994), Italian football player and manager

• Onofrio Gabrielli (1619–1706), Italian painter

• Onofrio del Grillo (1714-1787), Italian papal nobleman

• Onofrio Antonio Gisolfi (died 1656), Italian engineer and architect

• Onofrio Montesoro (1647–1722), Italian Roman Catholic prelate

• Onofrio Palumbo (1606–1650s), Italian painter

• Onofrio Panvinio (1529–1568), Italian Augustinian friar, historian and antiquary

• Onofrio de Ponte (died 1676), Italian Roman Catholic prelate

• Onofrio Puglisi (died 1679), Italian mathematician

• Onofrio di Santa Croce (died 1471), Italian Roman Catholic cardinal

• Onofrio Sciortino (died 1959), Italian-American mobster

• Francesco Onofrio Manfredini (1684–1762), Italian composer, violinist and church musician

• Francesco Onofrio Odierna (1644–1736), Italian Roman Catholic prelate

• Lorenzo Onofrio Colonna, multiple people

As a surname

• Al Onofrio (1921–2004), American football player and coach

• Judy Onofrio (born 1939), American artist

• Marco Onofrio (born 1971), Italian writer, essayist and literary critic

• Anna-Joséphine Dufour-Onofrio (1817–1901), French-Swiss businesswoman

See also

• D'Onofrio

• Onofri

• Sant'Onofrio (disambiguation)