Pierre-Simon is a French masculine given name, and may refer to:

• Pierre-Simon Ballanche (1776–1847), a French writer and counterrevolutionary philosopher

• Pierre Simon Fournier (1712–1768), a French typographer

• Pierre-Simon Girard (1765–1836), a French mathematician and engineer

• Pierre-Simon Laplace (1749–1827), a French mathematician and astronomer

See also

• Pierre Simon

• Pierre Simon (1885–1977)