Quaye is a common Ghanaian surname. Notable people with the surname include:

• Abdullah Quaye (born 1980), Ghanaian football midfielder

• Benjamin W. Quartey Quaye Papafio (1859–1924), physician and politician in the Gold Coast

• Caleb Quaye (born 1948), English Afro-European rock guitarist and studio musician

• Daniel Quaye (born 1980), Ghanaian football defender

• Finley Quaye (born 1974), Scottish musician

• Ko Quaye (born 1987), Canadian football defensive tackle

• Lawrence Quaye (born 1984), Ghana born naturalized Qatari footballer

• Paul Quaye (born 1995), Spanish-born Ghanaian footballer

• Peter Ofori-Quaye (born 1980), Ghanaian professional association football player

• Philemon Quaye (1924–2010), Ghanaian soldier, politician, diplomat and religious leader

• Raphael M. Quaye (born 1975), Liberian basketball player

• Shamo Quaye (1971–1997), Ghanaian footballer

• Terri Quaye (born 1940), English singer, pianist, and percussionist