Route 151, or Highway 151, may refer to:

Canada

• Prince Edward Island Route 151

Costa Rica

• National Route 151

India

• National Highway 151 (India)

Ireland

• R151 road (Ireland)

Japan

• Japan National Route 151

Korea, South

• Seocheon–Gongju Expressway

United Kingdom

• road

• B151 road

United States

• U.S. Route 151

• Alabama State Route 151

• Arkansas Highway 151

• California State Route 151

• Colorado State Highway 151

• Connecticut Route 151

• Florida State Road 151

• Georgia State Route 151

• Hawaii Route 151 (former)

• Illinois Route 151

• Kentucky Route 151

• Louisiana Highway 151

• Maine State Route 151

• Maryland Route 151

• Massachusetts Route 151

• M-151 (Michigan Highway) (former)

• Missouri Route 151

• New Hampshire Route 151

• New Jersey Route 151 (former)

• New York State Route 151

• North Carolina Highway 151

• Ohio State Route 151

• Oklahoma State Highway 151

• Pennsylvania Route 151

• South Carolina Highway 151

• Tennessee State Route 151

Texas State Highway 151

• Texas State Highway Loop 151

• Texas State Highway Spur 151

• Utah State Route 151

• Virginia State Route 151

• Washington State Route 151 (former)

• Wyoming Highway 151

• Territories:

• Puerto Rico Highway 151