Sapiro is one variant of the Ashkenazi Jewish surname Shapiro. Notable people with the surname include:

• Aaron Sapiro (1884–1959), American cooperative activist and lawyer

• Evgeniy Sapiro (1934–2024), Soviet-Russian economist and politician

• Gisèle Sapiro (born 1965), French sociologist and historian

• Guillermo Sapiro (born 1966), Uruguayan computer scientist, electrical engineer, and professor

• Ilya Piatetski-Shapiro (1929–2009), Soviet-born Israeli mathematician

• Miriam Sapiro (born 1960), American politician

• Shireen Sapiro (born 1991), South African Paralympic swimmer

• Virginia Sapiro (born 1951), American political scientist and political psychologist

See also

• Sapiro, a fictional kingdom in Encantadia, a Filipino fantasy franchise

• Speyer, a city in Germany

Similar variants of the surname Shapiro:

• Chapiro

• Schapira

• Schapiro

• Shapero

• Shapira

• Spiro

• Szapiro

• Szpiro