Segel, and its variants including Segal or Siegel, is a primarily an Ashkenazi Jewish family name.

Notable people with the surname include:

• Arthur I. Segel, American economist

• Binjamin W. Segel (1867–1931), author

• Harold Segel (1930–2016), American professor

• Jason Segel (born 1980), American actor

• Jonathan Segel (born 1963), American composer

• Joseph Segel (1931–2019), American businessman

• Lee Segel (1932–2005), American applied mathematician

See also

• Chagall (disambiguation)

• Segal

• Siegel

• Sigel (disambiguation)