Sesay is a common surname among the Mandingo, Temne, Loko, Limba and Kuranko people of Sierra Leone, and may refer to:

• Alimamy Sesay (1987), Sierra Leonean football player

• Ansu Sesay (1976), American professional basketball player

• Benjamin Sesay (1981), Sierra Leonean international football player

• Brima Sesay (19812009), Sierra Leonean international football goalkeeper

• David Sesay (1998), British football player

• Hassan Koeman Sesay (1986), Sierra Leonean international football player

• Hassan Mila Sesay (1987), Sierra Leonean international football player

• Ibrahim Sesay, member of parliament of Sierra Leone

• Isha Sesay, British journalist of Sierra Leonean descent and anchor of CNN International

• Issa Hassan Sesay (1970), served as senior officer and commander in the Revolutionary United Front and AFRC/RUF forces in their insurrection against the government of Sierra Leone

• Kadi Sesay, formally Kadiatu Sesay, former Sierra Leone Minister of Trade and Industry and mother of CNN International anchor Isha Sesay

• Kadija Sesay, also called Kadija George, is a British writer and poet of Sierra Leonean descent

• Lamin-Sullay Sesay (19652004), also called , Sierra Leonean writer and journalist

• Maria Sesay, Sierra Leonean media host and culture curator

• Muwahid Sesay (1984), Sierra Leonean international football striker

• Sulaiman Sesay Fullah, Sierra Leonean international footballer

• Zainab Bangura (born Zainab Hawa Sesay, 1959), Sierra Leone minister of foreign affairs