• The Simoni people were a Native American group in Texas.

Simoni is a surname, and may refer to:

• Alexandre Simoni (born 1979), Brazilian tennis player

• Dario Simoni (1901–1984), American set decorator

• Elisa Simoni (born 1973), Italian politician

• Ernest Simoni (born 1928), Albanian Roman Catholic cardinal

• Giampiero Simoni (born 1969), Italian racing driver

• Gilberto Simoni (born 1971), Italian professional road bicycle racer

• Giuseppe Simoni (born 1944), Italian biologist and scientist

• Gjon Simoni (1936–1999), Albanian musicologist and composer

• Jane M. Simoni, American clinical psychologist

• Luigi Simoni (1939–2020), Italian football manager

• Renato Simoni (1875–1952), Italian journalist

• Sabrina Simoni (born 1969), Italian conductor

• Simone Simoni (1532–1602), Italian philosopher and physician

• Ugo Simoni (born 1938), Italian former sports shooter

• Zef Simoni (1928–2009), Albanian Roman Catholic bishop