Substance may refer to:

• Matter, anything that has mass and takes up space

Chemistry

• Substance (chemistry), a material with a definite chemical composition

• Drug, a chemical agent affecting an organism

Arts, entertainment, and media

Music

• Substance, a 2002 album by Blank & Jones

• Substance (Joy Division album), 1988

• Substance 1987, a New Order album

• "Substance", a song by Haste the Day on the album Burning Bridges

• "Substance" (song), a 2022 song by Demi Lovato

• "Substance", a 2000 dance track by Blu Peter

Other media

• The Substance, 2024 film

• SubStance, an interdisciplinary journal on literature published by the University of Wisconsin Press

• Metal Gear Solid 2: Substance, an update of the video game Metal Gear Solid 2: Sons of Liberty

Religion and philosophy

• Dravya, a term used in Jainism to refer a substance

• Ousia, term for substance in ancient Greek philosophy and Christian theology

• Substance theory, an ontological theory positing that a substance is distinct from its properties

Software

• Substance 3D Modeler, software from Adobe for 3D content creation

See also

• Substance use (disambiguation)

• Substance control (disambiguation)

• Substantial (rapper)