TBC1 domain family member 3 is a protein that in humans is encoded by the TBC1D3 gene. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in Rab GTPase signaling and vesicle trafficking.

In humans, the NPEPPS-TBC1D3 fusion (transcriptional readthrough) transcripts are the predominant TBC1D3 isoforms.

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