TCA may refer to:

Chemistry and biochemistry

• Toxin complex a, an insecticidal toxin complex produced by Photorhabdus luminescens bacteria

• Tricarboxylic acid cycle, an alternate name for the citric acid cycle pathway in cellular metabolism

• Trichloroacetic acid, chemical with many applications in biochemistry, cosmetic treatments, and medicine

• 2,4,6-Trichloroanisole, cause of cork taint in wine

• Tricyclic antidepressant, a class of medications

• TCA, a codon for the amino acid serine

Culture and media

• Taiwanese Cultural Association

• Tekeyan Armenian Cultural Association, a network of Armenian cultural organisations

• Television Critics Association

• The Canadian Amateur, radio amateur magazine

• Tribune Content Agency, a syndication company owned by Tribune Publishing

• Triple Crown of Acting is a term used in the American entertainment industry to describe actors who have won a competitive Academy Award, Emmy Award, and Tony Award in the acting categories

• Twentieth Century Animation, the animation division of 20th Century Studios

Economics and finance

• Transaction cost analysis

• Total cost of acquisition

• True cost accounting

Education

• The Classical Academy (Colorado), Colorado Springs, US

• Trinity Christian Academy (Deltona, Florida), US

• Trinity Christian Academy (Jackson, Tennessee), US

Organizations

• The Consulting Association, British organisation involved in blacklisting construction workers

• Total Community Action, New Orleans, USA; non-profit supporting disadvantaged residents

• Trans-Canada Air Lines, predecessor to Air Canada

• Train Collectors Association, for collectors/operators of toy trains

• Transportes Carga Aérea, a defunct Brazilian airline

Politics and government

• Taiwan Constitution Association, a political party in Taiwan

• EU–UK Trade and Cooperation Agreement, between the UK and the EU (2020)

• The Competition Authority (Ireland) (2002–2014)

Other uses

• Terminal control area, a volume of controlled airspace

• Topology change acknowledgement, a message in the 802.1D Spanning Tree Protocol (STP)

• Transportation Corridor Agencies, a toll road authority in Orange County, California

• Traumatic cardiac arrest, due to trauma

• Tennant Creek Airport, Northern Territory, Australia (IATA code: TCA)

• Turks and Caicos Islands, country code

• Tropical Cyclone Advisory, tropical forecast service for international aviation safety