USS Mobile may refer to:

• USS Mobile, a former name of

• , the former Confederate blockade runner Tennessee originally launched in 1854

• , the former German liner SS Cleveland used to transport U.S. troops home from Europe after World War I

• , a Cleveland-class light cruiser

• , a Charleston-class amphibious cargo ship

• , a Ticonderoga-class guided-missile cruiser

• , an Independence-class littoral combat ship