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Wikipedia / Calphostin

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides. The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC). The most potent member of the series, calphostin C, has found use as a biochemical tool because of this activity.

Calpohostin

R1

R2

Calphostin A

Bz

Bz

Calphostin B

Bz

H

Calphostin C

Bz

4-(HO)Bz

Calphostin D

H

H

Calphostin I

4-(HO)Bz

4-(HO)Bz

Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).

References