Neuronal Calcium Sensor is a large family of proteins which work as calcium dependent molecular switches and includes members like Frequenin (NCS1), recoverin, GCAP, neurocalcin, visinin etc. All the members carry 4 EF hand motifs (out of which only 2 or 3 bind calcium) and an N-myristoyl group.

Members of NCS family

• Highly evolutionarily conserved

• NCS1 (Frequenin)

• VILIP-1 (Visinin-like-protein-1)

• HPCAL4 (Visinin-like-protein-2)

• HPCAL1 (Visinin-like-protein-3)

• hippocalcin

• neurocalcin

• recoverin

• Guanylate cyclase activator proteins (GCAPs)

• Potassium Channel interacting proteins (KChIPs 1–4), including:

KCNIP1, KCNIP2, Calsenilin or DREAM/KChIP-3/KCNIP3 (downstream regulatory element antagonist modulator/potassium channel interacting protein), KCNIP4

References

External links

• NCS proteins