USS Boston may refer to:

• , was a gundalow launched in 1776 and burned to avoid capture by the British on 13 October 1776

• , was a 24-gun frigate, commissioned in 1777 and captured by the British in 1780

• , was a 28-gun frigate lost during the War of 1812

• , was an 18-gun sloop of war commissioned in 1826 and wrecked in the Bahamas in 1846

• , was a protected cruiser commissioned in 1887 and took part in the Spanish–American War

• , was a heavy cruiser commissioned 1943 and active in both World War II and the Korean War

• , was a Los Angeles-class nuclear attack submarine decommissioned in 1999