USS Colorado may refer to the following ships of the United States Navy:

• , a three-masted steam screw frigate in commission from 1858–1876

• , a Pennsylvania-class armored cruiser in commission from 1905–1927

• , a Colorado-class battleship in commission from 1923–1947

• , a Virginia-class nuclear-powered fast attack submarine commissioned in 2018, in active service

In fiction:

• USS Colorado (SSBN-753), a fictional Ohio-class submarine featured in the 2012 TV series Last Resort