Spangler is a surname. Notable people with the surname include:

• Aaron Spangler (born 1971), American sculptor and printmaker

• Al Spangler (born 1933), American baseball player

• Amy Spangler (born 1949), American breastfeeding activist, nurse, author, and teacher

• Angela Bradburn-Spangler (born 1968), American high jumper

• Clemmie Spangler (1932–2018), American businessman

• David Spangler (congressman) (1796–1856), American politician from Ohio

• David Spangler (born 1945), American spiritualist

• Donald H. Spangler (1918–1942), United States Naval officer

• Edmund Spangler (1825–1875), alleged conspirator of the Abraham Lincoln assassination

• Gary Spangler (born ?), American music executive

• Gene Spangler (1922–2010), American football player

• Harrison E. Spangler (1879–1965), American politician and chairman of the Republican National Committee

• Jacob Spangler (1767–1843), American politician from Pennsylvania

• James M. Spangler (1848–1915), American inventor and janitor; designed the first portable electric vacuum cleaner

• Jean Spangler (1923–disappeared 1949), American dancer, model, and actress

• Jenny Spangler (born 1963), American long-distance runner

• Ken Spangler (born 1967), Canadian hockey player

• Lester Spangler (1906–1933), American race car driver

• Lisa Spangler (born 1994), American mixed martial artist

• Matthew Spangler (born ?), American playwright, director, and professor

• Paul Spangler (1899–1994), American naval surgeon and long-distance runner

• Robert Spangler (1933–2001), American serial killer

• Robert Spangler (American football) (1917–1992), American football and basketball player, and coach

• Ryan Spangler (born 1991), American basketball player

• Spanky Spangler (born ?), American stunt man and actor

• Steve Spangler (born 1966), American television personality, scientist, author, and businessman

• Tommy Spangler (born 1961), American football coach

Fictional characters

• Edwin Spangler, television role from Malcolm in the Middle

• Moist von Lipwig, (alias Albert Spangler), character from Terry Pratchett’s Discworld series of novels