USS Detroit may refer to:

• USS Detroit (1813), a 20-gun ship captured from the British during the Battle of Lake Erie, 10 September 1813, laid up almost immediately, and sold in 1825.

• USS Canandaigua (1862) was a Sacramento-class sloop named Detroit from 15 May to 10 August in 1869.

• Detroit, a planned Algoma-class sloop, was cancelled in 1866

• was a cruiser in use from 1893 to 1904

• was a light cruiser in service from 1923 to 1946

• was a fast combat support ship commissioned in 1970 and decommissioned in 2005

• is a launched in 2014 and decommissioned in 2023.