Echenique is a surname of Basque origin. Echenique, (spelled Etxenike in standard Basque means "close to the house". Other spelling variants are Echeñique and Etchenique. Notable people with the surname include:

Sport

• Karla Echenique, Dominican volleyball player

• José Echenique, Venezuelan basketball player

• Rafael Echenique, Argentine golfer

Music

• Cecilia Echenique, Chilean singer-songwriter

• Benjamín Juárez Echenique, Mexican popular musical conductor

• José Miguel "Negro" Piñera Echenique, Chilean musician

Politics

• Gertrudis Echenique, Chilean First Lady between 1896 and 1901. Wife of Federico Errázuriz Echaurren

• José Rufino Echenique, Peruvian politician. President of Peru from 1851 until 1855

• Pablo Echenique Robba, Spanish scientist and politician

• Sebastián Piñera Echenique, Chilean politician, member of the National Renewal (RN)

• José Piñera Echenique, Chilean economist

Science

• Pedro Miguel Echenique, Spanish theoretical physicist and from 1980 to 1984 minister of education in the Basque Country

Literature

• Alfredo Bryce Echenique, a Peruvian writer