Fluorenone is an organic compound with the chemical formula , and is a ketone with a fluorene moiety. It is a bright yellow, fluorescent solid.

Synthesis and reactions

It is synthesised by aerobic oxidation of fluorene:

Fluorenone sustains up to four nitro groups giving 2,4,5,7-tetranitrofluorenone.

Applications

Several substituted fluorenones are biologically active as antibiotic, anticancer, antiviral, or neuromodulatory compounds.

Some substituted azafluorenones are biologically active, such as the naturally occurring antimicrobial compound onychine (1-methyl-4-azafluorenone). The compound 1,8-diazafluoren-9-one is used for fingerprint detection.

Drugs

Fluorenone is used to synthesize:

• A drug called IPS-339 [60979-28-4].

• An analog of 2-MDP.

• Paranyline (aka Renytoline, Mer 27).

• Via a Beckmann rearrangement, phenanthridone [1015-89-0]. This compound is used in the synthesis of fantridone.

• An analog of amitriptyline, as reported by Roche: [4684-13-3].

See also

• Fluorenol

• Chlorflurenol

References

External links

• Material Safety Data Sheet