Signaling peptide receptor is a type of receptor which binds one or more signaling peptides or signaling proteins.

An example is the tropomyosin receptor kinase B (TrkB), which is bound and activated by the neurotrophic protein brain-derived neurotrophic factor (BDNF). Another example is the μ-opioid receptor (MOR), which is bound and activated by the opioid peptide hormone β-endorphin.

Adiponectin receptor

AdipoR1

Agonists

Peptide

• Adiponectin

• ADP-355

• ADP-399

Non-peptide

• AdipoRon

• (–)-Arctigenin

• Arctiin

• Gramine

• Matairesinol

Antagonists

Peptide

• ADP-400

AdipoR2

Agonists

Peptide

• Adiponectin

• ADP-355

• ADP-399

Non-peptide

• AdipoRon

• Deoxyschizandrin

• Parthenolide

• Syringing

• Taxifoliol

Antagonists

Peptide

• ADP-400

Angiotensin receptor

Bradykinin receptor

Agonists

• Bradykinin

• Kallidin

Antagonists

• FR-173657

• Icatibant

• LF22-0542

Calcitonin gene-related peptide receptor

Agonists

• Amylin

• CGRP

• Pramlintide

Antagonists

• Atogepant

• BI 44370 TA

• CGRP (8-37)

• MK-3207

• Olcegepant

• Rimegepant

• SB-268262

• Telcagepant

• Ubrogepant

Antibodies

• Eptinezumab

• Erenumab

• Fremanezumab

• Galcanezumab

Cholecystokinin receptor

CCKA

Agonists

• Cholecystokinin

Antagonists

• Amiglumide

• Asperlicin

• Devazepide

• Dexloxiglumide

• Lintitript

• Lorglumide

• Loxiglumide

• Pranazepide

• Proglumide

• Tarazepide

• Tomoglumide

CCKB

Agonists

• Cholecystokinin

• CCK-4

• Gastrin

• Pentagastrin (CCK-5)

Antagonists

• Ceclazepide

• CI-988 (PD-134308)

• Itriglumide

• L-365,360

• Netazepide

• Proglumide

• Spiroglumide

Unsorted

Antagonists

• Nastorazepide

Corticotropin-releasing hormone receptor

CRF1

Agonists

• Cortagine

• Corticorelin

• Corticotropin-releasing hormone

• Sauvagine

• Stressin I

• Urocortin

Antagonists

• Antalarmin

• Astressin-B

• CP-154,526

• Emicerfont

• Hypericin

• LWH-234

• NBI-27914

• NBI-74788

• Pexacerfont

• R-121919

• TS-041

• Verucerfont

CRF2

Agonists

• Corticorelin

• Corticotropin-releasing hormone

• Sauvagine

• Urocortin

Antagonists

• Astressin-B

Cytokine receptor

Endothelin receptor

Agonists

• Endothelin 1

• Endothelin 2

• Endothelin 3

• IRL-1620

• Sarafotoxin

Antagonists

• A-192621

• Ambrisentan

• Aprocitentan

• Atrasentan

• Avosentan

• Bosentan

• BQ-123

• BQ-788

• Clazosentan

• Darusentan

• Edonentan

• Enrasentan

• Fandosentan

• Feloprentan

• Macitentan

• Nebentan

• Sitaxentan

• Sparsentan

• Tezosentan

• Zibotentan

Galanin receptor

GAL1

Agonists

• Galanin

• Galanin (1-15)

• Galanin-like peptide

• Galmic

• Galnon

• NAX 810-2

Antagonists

• C7

• Dithiepine-1,1,4,4-tetroxide

• Galantide (M15)

• M32

• M35

• M40

• SCH-202596

GAL2

Agonists

• Galanin

• Galanin (1-15)

• Galanin (2-11)

• Galanin-like peptide

• Galmic

• Galnon

• J18

• NAX 810-2

Antagonists

• C7

• Galantide (M15)

• M32

• M35

• M40

• M871

GAL3

Agonists

• Galanin

• Galanin (1-15)

• Galmic

• Galnon

Antagonists

• C7

• Galantide (M15)

• GalR3ant

• HT-2157

• M32

• M35

• M40

• SNAP-37889

• SNAP-398299

Growth hormone secretagogue receptor

Growth hormone receptor

Growth-hormone-releasing hormone receptor

Glucagon-like peptide receptor

GLP-1

Agonists

• Albiglutide

• Beinaglutide

• Dulaglutide

• Efpeglenatide

• Exenatide

• GLP-1

• Langlenatide

• Liraglutide

• Lixisenatide

• Oxyntomodulin

• Pegapamodutide

• Semaglutide

• Taspoglutide

GLP-2

Agonists

• Apraglutide

• Elsiglutide

• Glepaglutide

• GLP-2

• Teduglutide

Others

Propeptides

• Preproglucagon

• Proglucagon

Glucagon receptor

Agonists

• Dasiglucagon

• Glucagon

• Oxyntomodulin

Antagonists

• Adomeglivant

• L-168,049

• LGD-6972

Propeptides

• Preproglucagon

• Proglucagon

Gonadotropin-releasing hormone receptor

Gonadotropin receptor

Growth factor receptor

Insulin receptor

Agonists

• Chaetochromin (4548-G05)

• Insulin-like growth factor 1

• Insulin-like growth factor 2

• Insulin

• Insulin aspart

• Insulin degludec

• Insulin detemir

• Insulin glargine

• Insulin glulisine

• Insulin lispro

• Mecasermin

• Mecasermin rinfabate

Antagonists

• BMS-754807

• S661

• S961

Kinase inhibitors

• Linsitinib

Antibodies

• Xentuzumab (against IGF-1 and IGF-2)

KiSS1-derived peptide receptor

Agonists

• Kisspeptin (kisspeptin-54, metastin)

• Kisspeptin-10

• KISS1-305

• MVT-602 (RVT-602, TAK-448)

• TAK-683

Antagonists

• Kisspeptin-234

Leptin receptor

Agonists

• Leptin

• Metreleptin

Melanin-concentrating hormone receptor

MCH1

Agonists

• Melanin-concentrating hormone

Antagonists

• ATC-0065

• ATC-0175

• GW-803430

• NGD-4715

• SNAP-7941

• SNAP-94847

MCH2

Agonists

• Melanin-concentrating hormone

Melanocortin receptor

Neuropeptide FF receptor

Agonists

• Neuropeptide AF

• Neuropeptide FF

• Neuropeptide SF (RFRP-1)

• Neuropeptide VF (RFRP-3)

Antagonists

• BIBP-3226

• RF9

Neuropeptide S receptor

Agonists

• Neuropeptide S

Antagonists

• ML-154

• SHA-68

Neuropeptide Y receptor

Y1

Agonists

• Neuropeptide Y

• Peptide YY

Antagonists

• BIBO-3304

• BIBP-3226

• BVD-10

• GR-231118

• PD-160170

Y2

Agonists

• 2-Thiouridine 5'-triphosphate

• Neuropeptide Y

• Neuropeptide Y (13-36)

• Peptide YY

• Peptide YY (3-36)

Antagonists

• BIIE-0246

• JNJ-5207787

• SF-11

Y4

Agonists

• GR-231118

• Neuropeptide Y

• Pancreatic polypeptide

• Peptide YY

Antagonists

• UR-AK49

Y5

Agonists

• BWX-46

• Neuropeptide Y

• Peptide YY

Antagonists

• CGP-71683

• FMS-586

• L-152,804

• Lu AA-33810

• MK-0557

• NTNCB

• Velneperit (S-2367)

Neurotensin receptor

NTS1

Agonists

• Neurotensin

• Neuromedin N

Antagonists

• Meclinertant

• SR-142948

NTS2

Agonists

• Neurotensin

Antagonists

Levocabastine

• SR-142948

Opioid receptor

Orexin receptor

Oxytocin receptor

Prolactin receptor

Parathyroid hormone receptor

Agonists

• Abaloparatide

• Parathyroid hormone

• Parathyroid hormone-related protein (PTHrP)

• Semparatide

• Teriparatide

Relaxin receptor

Agonists

• Insulin-like factor 3

• Relaxin (1, 2, 3)

• Serelaxin

Somatostatin receptor

Tachykinin receptor

Thyrotropin-releasing hormone receptor

Agonists

• Azetirelin

• JTP-2942

• Montirelin

• Orotirelin

• Posatirelin

• Protirelin

• Rovatirelin

• RX-77368 (thymoliberin)

• Taltirelin

• TRH (TRF)

Thyrotropin receptor

Agonists

• Thyrotropin alfa

• TSH (thyrotropin)

Vasopressin receptor

Vasoactive intestinal peptide receptor and Pituitary adenylate cyclase-activating peptide

VIPR1

Agonists

Peptide

• Bay 55-9837

• LBT-3393

• PACAP

• VIP

VIPR2

Agonists

Peptide

• LBT-3627

• PACAP

• VIP

PAC1

Agonists

• PACAP

• PACAP (1-27)

• PACAP (1-38)

Antagonists

• PACAP (6-38)

Unsorted

• PHI

• PHM

• PHV

Others

Endogenous

• Adrenomedullin

• Apelin

• Asprosin

• Bombesin

• Calcitonin

• Carnosine

• CART

• CLIP

• DSIP

• Enteroglucagon

• Formyl peptide

• GALP

• GIP

• GRP

Integrin ligands

• collagens

• fibrinogen

• fibronectin

• laminins

• ICAM-1

• ICAM-2

• osteopontin

• VCAM-1

• vitronectin

• Kininogens

• Motilin

Natriuretic peptides

• ANP

• BNP

• CNP

• urodilatin

• Nesfatin-1

• Neuromedin B

• Neuromedin N

• Neuromedin S

• Neuromedin U

• Obestatin

• Osteocalcin

• Resistin

• Secretin

• Thymopoietin

• Thymosins

• Thymulin

• Urotensin-II

• VGF

Exogenous

• Lifitegrast (LFA-1 antagonist)

See also

• Neuropeptide receptor

• Neurotransmitter receptor

References

External links