Caldesmon is a protein that in humans is encoded by the CALD1 gene.

Caldesmon is a calmodulin binding protein. Like calponin, caldesmon tonically inhibits the ATPase activity of myosin in smooth muscle.

-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Immunochemistry

In diagnostic immunochemistry, caldesmon is a marker for smooth muscle differentiation.

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