Manion may refer to:

• Clarence Manion (1896-1979), American conservative and Dean of Notre Dame.

• Daniel Anthony Manion (1942-2024), United States federal judge for the United States Court of Appeals for the Seventh Circuit

• Ed Manion (born 1952), American saxophone player

• Jack Manion (1877–1959), San Francisco Police Sergeant

• John Manion (1931-2010), Canadian civil servant

• Katherine Manion (1867–1956), American physician

• Robert James Manion (1881–1943), leader of the Conservative Party of Canada

• Manyam Zamindar of French Yanam.

See also

• Mannion

• James Mannon (born 1942), American sociologist