Schlessinger is a German surname meaning "from Silesia" (German: Schlesien). The Czechized form of the surname is Šlesingr (; feminine: Šlesingrová). Notable people with the surname include:

• Arthur M. Schlesinger Sr. (1888–1965), American historian and professor

• David Schlessinger (born 1936), Canadian-American biochemist, microbiologist and geneticist

• Joseph Schlessinger (born 1945), Israeli-American biochemist

• Laura Schlessinger (born 1947), American radio host and author

• Michael Schlessinger, American mathematician

• Michal Šlesingr (born 1983), Czech biathlete

See also

• Schlessinger Media, educational video distributor

• Schlesinger

• Shlesinger

• Slesinger