Prunella may refer to:

Arts and entertainment

• Prunella (fairy tale), an Italian fairy tale

• Prunella, a 1913 play in the United States with Marguerite Clark

• Prunella (film), a 1918 silent film

Plants and animals

• Prunella (bird), also known as accentors or dunnocks, a bird genus

• Prunella (plant), also known as self-heal, a plant genus

• Prunella (grape), a French wine grape better known as Cinsaut

Other uses

• Prunella (given name)

• Prunella (horse), a Thoroughbred racehorse and broodmare

• Prunella (cloth), an 18th-century worsted fabric

• Bargnolino, sometimes called prunella, Italian sloe gin