Histone deacetylase 1 (HDAC1) is an enzyme that in humans is encoded by the HDAC1 gene.

Function

Histone acetylation and deacetylation, catalyzed by multisubunit complexes, play a key role in the regulation of eukaryotic gene expression. The protein encoded by this gene belongs to the histone deacetylase/acuc/apha family and is a component of the histone deacetylase complex. It also interacts with retinoblastoma tumor-suppressor protein and this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2 MTA2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.

Interactions

HDAC1 has been shown to interact with:

• Androgen receptor,

• BCL6,

• BTG2,

• BUB1B,

• BUB1,

• BUB3,

• CBFA2T3,

• CDC20,

• CDH1,

• CHD3,

• CHD4,

• COUP-TFII,

• CTBP1,

• DDX17,

• DDX5,

• DNMT3A,

• DNMT3L,

• Death-associated protein 6,

• EED,

• EVI1,

• EZH2,

• FKBP3,

• GATA1,

• HMG20B,

• HSPA4,

• HUS1,

• Histone deacetylase 2,

• Homeobox protein TGIF1,

• Host cell factor C1,

• IFRD1,

• IKZF1,

• ING1,

• MBD3,

• MIER1,

• MLL,

• MTA1,

• MTA2,

• Mad1,

• Mdm2,

• Methyl-CpG-binding domain protein 2,

• Mothers against decapentaplegic homolog 2,

• MyoD,

• NFKB1,

• Nuclear receptor co-repressor 2,

• P21,

• PCNA,

• PHF21A,

• Prohibitin,

• Promyelocytic leukemia protein,

• RAD9A,

• RBBP4,

• RBBP7,

• RCOR1,

• RELA,

• RFC1,

• Retinoblastoma protein,

• Retinoblastoma-like protein 1,

• Retinoblastoma-like protein 2,

• SAP30,

• SATB1,

• SIN3A,

• SIN3B,

• SPEN,

• SUDS3,

• SUV39H1,

• Sp1 transcription factor,

• TOP2A,

• TOP2B, and

• Zinc finger and BTB domain-containing protein 16.

See also

• Histone deacetylase

• Histone deacetylase inhibitor

References

Further reading

External links