HNE may refer to:

• Hne, a Burmese musical instrument

• 4-Hydroxynonenal, produced by lipid peroxidation

• Chhattisgarhi language, spoken in India

• Hexanitroethane, an oxidizer

• Historic New England, an American historical society

• Home News Enterprises, an American publisher

• Michel Hne, New Caledonian football player

• Neutrophil elastase

• Harwich and North Essex, a UK Parliamentary Constituency

• Heure Normale de l'Est (Eastern time zone) in Canada.