REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.

Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).

Interactions

RCOR1 has been shown to interact with

• HDAC1,

• HDAC2,

• HMG20B,

• REST and

• PHF21A.

References

Further reading