Protein ariadne-2 homolog is a protein that is encoded by the ARIH2 gene in humans.

Function

ARIH2 influences development of Mll-Ell-induced acute myeloid leukemia and regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination, ARIH2 Ubiquitinates NLRP3 and Negatively Regulates NLRP3 Inflammasome Activation in Macrophages.

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Further reading