Isse or ISSE may refer to:

Places

• Isse, village and commune in north-eastern France

• Issé, village and commune in north-western France

Computing

• Information Systems Security Engineering

• Internet Streaming SIMD Extensions, an SIMD instruction set extension to the x86 architecture by Intel introduced in 1999

• Integer Streaming SIMD Extensions, an informal name for MMX extensions associated with 3DNow! extensions

Other uses

• Issé (opera), by André Cardinal Destouches

• International Secondary School Eindhoven, a school in the Netherlands

• International Students for Social Equality

• Hirsi Magan Isse (1935–2008), scholar and a leading figure of the Somali Revolution