BBSome complex assembly protein BBS10, also known as Bardet–Biedl syndrome 10 protein, is encoded in the human by the BBS10 gene.

Function

The Bardet-Biedl syndrome 10 protein has distant sequence homology to type II chaperonins. As a molecular chaperone, this protein may affect the folding or stability of other ciliary or basal body proteins. Inhibition of this protein's expression impairs ciliogenesis in preadipocytes.

Clinical significance

Mutations in this gene are associated with the Bardet–Biedl syndrome.

References

Further reading

External links

• GeneReviews/NIH/NCBI/UW entry on Bardet-Biedl Syndrome