Colosimo is an Italian surname. Notable people with the surname include:

• Big Jim Colosimo (1878–1920), Italian organized crime figure

• Gaspare Colosimo (1859–1940), Italian jurist and politician

• Simon Colosimo (born 1979), Australian soccer player

• Vince Colosimo (born 1966), Australian actor

See also

• Colosimi