One Small Step may refer to:

• "One small step for [a] man, one giant leap for mankind", a phrase spoken by Neil Armstrong as he became the first person to set foot on the Moon

• One Small Step (album), an album by John Butler

• One Small Step..., an album by Guy Manning

• One Small Step (novella), a 1990 novella by Reginald Hill

• One Small Step: The Story of the Space Chimps, a 2008 documentary film

• "One Small Step" (Star Trek: Voyager), an episode of the TV series

• "One Small Step", a song by Ayreon from Universal Migrator Part 1: The Dream Sequencer

• "One Small Step...", an episode (S04 E19) of the TV program EUReKA

• One Small Step (film), a 2018 Chinese-American animated short film

• one small stEP, an extended play album by American rock band Major Moment

• "One Small Step" (Doc), a 2025 episode of Doc