Sayler is a surname. Notable people with the surname include:

• Henry B. Sayler (1836–1900), American politician, cousin of Milton

• Jace Sayler (born 1979), American football player

• Milton Sayler (1831–1892), American politician

See also

• Battle of Sayler's Creek, fought April 6, 1865, southwest of Petersburg, Virginia

• Sayler Park, Cincinnati, neighborhood in Cincinnati, Ohio

• Sayler's Creek Battlefield near Farmville, Virginia