The class C G-protein-coupled receptors () are a class of G-protein coupled receptors that include the metabotropic glutamate receptors () and several additional receptors.

Structurally they are composed of four elements; an N-terminal signal sequence; a large hydrophilic extracellular agonist-binding region containing several conserved cysteine residues which could be involved in disulphide bonds; a shorter region containing seven transmembrane domains; and a C-terminal cytoplasmic domain of variable length. This protein family includes metabotropic glutamate receptors, the extracellular calcium-sensing receptors, the gamma-amino-butyric acid (GABA) type B receptors, and the vomeronasal type-2 receptorss.

Subfamilies

Calcium-sensing receptor-related

extracellular calcium-sensing receptor-related

• Calcium-sensing receptor ()

• GPRC6A ()

GABAB receptors

GABAB receptor (gamma-aminobutyric acid)

• GABAB receptor 1 ()

• GABAB receptor 2 ()

Metabotropic glutamate receptors

Metabotropic glutamate receptors (mGluR)

• mGluR1 ()

• mGluR2 ()

• mGluR3 ()

• mGluR4 ()

• mGluR5 ()

• mGluR6 ()

• mGluR7 ()

• mGluR8 ()

RAIG

Retinoic acid-inducible orphan G protein-coupled receptors (RAIG)

• RAIG1 ()

• RAIG2 ()

• RAIG3 ()

• RAIG4 ()

Taste receptors

Taste receptor

• Taste receptor, type 1, member 1 ()

• Taste receptor, type 1, member 2 ()

• Taste receptor, type 1, member 3 ()

Orphan

Class C Orphan receptors

• GPR158 ()

• GPR179 ()

• GPR156 ()

Other

• Bride of sevenless protein

• Vomeronasal receptor, type 2

References